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KMID : 0369819890190020093
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Jorunal of Korean Pharmaceutical Sciences
1989 Volume.19 No. 2 p.93 ~ p.98
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Relative Bioavailability of Commercially Available Rifampicin Capsules
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Shin Kwang-Bum
Cho Yong-Baik
Song Young-Joon
Kwak Hoy-Sung
Lee Min-Hwa
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Abstract
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The study was performed to compare the dissolution, diffusion and absorption characteristics using Sartorius dissolution and absorption simulator and in vivo bioavailability of commercially available ri-fampicin capsules. Both brands C and F showed similar dissolution patterns and absorption properties through artificial gastric barrier in Sartorius simulator. Diffusion rate constants through the membrane of brands C and F were 3.04 x 40‘3 and 2.88 x 10’3 cm/ min, respectively. Rifampicin capsules were ad-ministered orally to six fasted healthy volunteers according to cross-over design. The pharmacokinetic parameters between brands C and F, maximum plasma drug concentration (Cum), the time to reach
Cm“, absorption rate constant and area under the curve (AUCo_24h,), elimination rate constant, and amount of drUg excreted in urine were 6.11 and 7.27 pg/ml, 2.71 and 1.52 hr, 0.6371 and 1.6456 hr-l, 57.84 and 57.28 pg-hr/ml, 0.1891 and 0.1734 hr‘l, 119.98 and 119.93 mg, respectively. On the basis of experimental results, it was concluded that the bioavailability of brand C rifampicin capsules was almost the same as that of brand F rifampicin capsules.
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KEYWORD
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Rifampicin capsules, dissolution, absorption simulation, pharmacokinetic parameter, bioavailability
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